Objective To study the effective observation methods and nurse measures on spontaneous bacterial peritonitis in patients with liver cirrhosis.Method The observation methods and nursed measures on 152 cases of spontaneous bacterial peritonitis in patients with liver cirrhosis were analyzed retrospectively in this paper.Results The rate of cure and effective were 84.9%(129/152),no effective and mortality were 15.7(23/152)by accurate therapy combined with nursing in this study.Conclusions It can promote patients to rehabilitation,decrease complications and reduce mortality rate of cirrhosis by effective nursed measures and observation state of an illness carefully,and have important clinical significances