The derivatization conditions of amphetamines by GC/FID

Objective To investigate the conditions of derivatization and to get a better derivative reagents of Amphetamines.Method Three derivative reagents such as acetic anhydride,trifluoroacetic anhydride chloride and 3,5-dinitro-benzoylchloride were selected,the derivatization conditions and results were investigated and compared by using GC.Result Qualitative and quantitative analysis conditions to this kind of drugs after acetic acetylation were setup.Conclusion The regulation to the products and some quantitative parameters after derivatization by GC/FID were determined.