Experimental Study on Toxicity and Efficacy of Genkwa Flos stir-baked with Vinegar

Objective:To study toxicity and efficacy of Genkwa Flos by processing with Vinegar.Methods:Acute toxicity of LD50 was calculated using Bliss,using diuretic effects to research the effect of the ethanol extracts of from different polar parts of Genkwa Flos and Vinegar-preparing Genkwa Flos.Results:The toxicity of Genkwa Flos processed with vinegar was significantly reduced,the part of ethly acelate was part of toxicity.As compared with the control group,the diuretic effects of alcohol extract and the parts of petroleum ether and ethly acelate of Genkwa Flos and vinegar-preparing Genkwa Flos had significant differences.The diuretic effects of Vinegar-preparing Genkwa Flos were enhanced compared with Genkwa Flos.Conclusion:Vinegar-preparing Genkwa Flos can significantly reduce toxicity and enhance efficacy.The parts of ethyl acelate are both parts of harmacodynamics and toxicity.