Endoplasmic Reticulum Stress and Type 2 Diabete

Unfolded or misfolded proteins accumulating in endoplasmic reticulum and the disturbance of cells homeostasis will result in the endoplasmic reticulum stress.Endoplasmic reticulum stress to a certain extent lead to the restoration of cells internal environment.However,if the stress is too strong and lasting,the function of endoplasmic reticulum will be damaged and cell apoptosis will present.As one of the most sensitive cells of endoplasmic reticulum stress,pancreatic β-cells have an abundance of endoplasmic reticulum.Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress participate in the onset of diabete mellitus.