Objective: To discuss the clinical significance of detecting C-reactive protein(CRP) and troponinI(cTnI) in patients with acute coronary syndrome(ACS).Methods: To detect serum CRP and cTnI variation in 31 cases of unstable angina pectoris(UAP) patients,34 cases of stable angina patients(SAP),24 cases of acute myocardial infarction(AMI) patients or sudden death from heart disease in 6-8 h after symptoms broken out;then comparied with control group and analyze correlation of CRP and cTnI with the incidence of cardiac events.Results: cTnI and CRP level of UAP group,SAP group,AMI group were higher than control group,and the higher of the content,the higher of the heart attack incidence.Its content discretion order was UAP groupAMI groupSAP group.cTnI and CRP level of UAP group and AMI group were higher than control group,there were significance differerences between AMI group and CRP group(P0.05),then there were no significance difference between SAP group and control group(P0.05).Conclusion: CRP and cTnI joint detection have higher clinical significance for diagnosis and prognosis of ACS.