Expression of CXCR4 and its Relationship with Prognosis of Colorectal Cancer

[Purpose] To investigate expression of CXCR4 and its relationship with prognosis of colorectal cancer.[Methods] The expression of CXCR4 in 70 cases with colorectal cancer tissue and 14 cases with cancer adjacent tissue was detected by immunohistochemistry.[Results] The positive rate of CXCR4 in colorectal cancer(57.1%,40/70) was significantly higher than that in cancer adjacent tissue(14.3%,2/14)(P0.01).The positive expression of CXCR4 was related to Dukes' stage(P=0.041) and lymph node metastasis(P=0.018).The disease free survival rate in CXCR4 positive expression group was significantly better than that in negative expression group(P = 0.008).[Conclusion] CXCR4 is over expression in colorectal cancer,and it relate to carcinogenesis and prognosis of colorectal cancer.