生物
病毒学
细小病毒
水禽
血清转化
病毒
鹅
侏儒症
亚临床感染
喙
砂囊
萎缩
动物
遗传学
动物科学
栖息地
古生物学
基因
生态学
作者
Hao Chen,Dou Yu,Yi Tang,Xiaoqiang Zheng,Xiaoyu Niu,Jing Yang,Xianglong Yu,Youxiang Diao
标识
DOI:10.1016/j.vetmic.2015.11.034
摘要
Infection of clinically susceptible ducks, including cherry valley and Muscovy ducks, with a novel goose parvovirus (GPV)-related virus (N-GPV) can result in beak atrophy and dwarfism syndrome (BADS). To obtain new insights into the host range and pathogenic potential of this novel waterfowl parvovirus, cherry valley ducklings (n = 20) were experimentally infected with N-GPV strain SDLC01. An equal number of ducklings served as uninfected controls. The appearance of clinical signs, histopathological changes, viral shedding, and seroconversion was monitored for 20 days post-infection. Infection status of all ducks was monitored using indirect ELISA, virus neutralization test, nested PCR, clinical indicators, and microscopic examination. Three ducks developed the typical clinical, gross, and histological changes of BADS. By study day 6, the infected ducks had seroconverted to N-GPV. The antibodies raised were neutralizing against the SDLC01 strain in vitro. Here we successfully developed an experimental infection model for studying the pathogenicity and role of N-GPV in BADS.
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