依西酞普兰
诺曲普利
中止
不利影响
抗抑郁药
萧条(经济学)
精神科
医学
便秘
检查表
内科学
心理学
阿米替林
焦虑
认知心理学
经济
宏观经济学
作者
Rudolf Uher,Anne Farmer,Neven Henigsberg,Marcella Rietschel,Ole Mors,Wolfgang Maier,Dejan Kozel,Joanna Hauser,Daniel Souery,Anna Placentino,Jana Strohmaier,Nader Perroud,Astrid Zobel,Aleksandra Rajewska‐Rager,Moica Zvezdana Dernovsek,Erik Roj Larsen,Petra Kalember,C Giovannini,Mara Isabel Barreto,Peter McGuffin,Katherine J. Aitchison
标识
DOI:10.1192/bjp.bp.108.061960
摘要
Background Adverse drug reactions are important determinants of non-adherence to antidepressant treatment but their assessment is complicated by overlap with depressive symptoms and lack of reliable self-report measures. Aims To evaluate a simple self-report measure and describe adverse reactions to antidepressants in a large sample. Method The newly developed self-report Antidepressant Side-Effect Checklist and the psychiatrist-rated UKU Side Effect Rating Scale were repeatedly administered to 811 adult participants with depression in a part-randomised multicentre open-label study comparing escitalopram and nortriptyline. Results There was good agreement between self-report and psychiatrists' ratings. Most complaints listed as adverse reactions in people with depression were more common when they were medication-free rather than during their treatment with antidepressants. Dry mouth (74%), constipation (33%) and weight gain (15%) were associated with nortriptyline treatment. Diarrhoea (9%), insomnia (36%) and yawning (16%) were more common during treatment with escitalopram. Problems with urination and drowsiness predicted discontinuation of nortriptyline. Diarrhoea and decreased appetite predicted discontinuation of escitalopram. Conclusions Adverse reactions to antidepressants can be reliably assessed by self-report. Attention to specific adverse reactions may improve adherence to antidepressant treatment.
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