兴奋
压力源
心理干预
健康衰老
背景(考古学)
长寿
干预(咨询)
心理学
人口
老年学
人口老龄化
成功老龄化
医学
临床心理学
生物
环境卫生
精神科
内分泌学
古生物学
氧化应激
作者
Marie‐Christine Pardon
出处
期刊:Dose-response
[SAGE]
日期:2009-10-13
卷期号:8 (1): dose-response.0
被引量:12
标识
DOI:10.2203/dose-response.09-020.pardon
摘要
The aging of the population brings new health challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension strategy and how it can be applied to the human. There is some evidence that the anti-aging benefits of lifestyle factors, such as diet, exercise or engaging in activities may be achieved via hormetic regulation. This supports the validity of the concept in human. There are, however, gaps in knowledge and ethical barriers that need to be addressed to establish the suitability of the approach to the clinical context or the general geriatric population. In particular, we need to find out which stressors are safe for use as anti-aging interventions, when they have to be applied to achieve maximal benefits, how their therapeutic potential is altered by changes in the stress system induced by age and pathological conditions, and the extent to which the occurrence of adverse versus positive effects depends on interacting genetic and experiential factors.
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