异三聚体G蛋白
G蛋白偶联受体
信号转导
细胞生物学
G蛋白
变构调节
支架蛋白
Gqα亚单位
效应器
细胞内
生物
化学
受体
生物化学
作者
Angeline M. Lyon,Veronica Taylor,John J.G. Tesmer
标识
DOI:10.1016/j.tips.2013.10.008
摘要
The heterotrimeric G protein Gαq is a central player in signal transduction, relaying signals from activated G-protein-coupled receptors (GPCRs) to effectors and other proteins to elicit changes in intracellular Ca(2+), the actin cytoskeleton, and gene transcription. Gαq functions at the intracellular surface of the plasma membrane, as do its best-characterized targets, phospholipase C-β, p63RhoGEF, and GPCR kinase 2 (GRK2). Recent insights into the structure and function of these signaling complexes reveal several recurring themes, including complex multivalent interactions between Gαq, its protein target, and the membrane, that are likely essential for allosteric control and maximum efficiency in signal transduction. Thus, the plasma membrane is not only a source of substrates but also a key player in the scaffolding of Gαq-dependent signaling pathways.
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