光学镊子
驱动蛋白
干涉测量
物理
微管
时间分辨率
灵敏度(控制系统)
运动蛋白
分子马达
光学
材料科学
纳米技术
生物
工程类
电子工程
细胞生物学
作者
Karel Svoboda,Christoph F. Schmidt,Bruce J. Schnapp,Steven M. Block
出处
期刊:Nature
[Springer Nature]
日期:1993-10-01
卷期号:365 (6448): 721-727
被引量:1763
摘要
Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed their motion under controlled loads by interferometry. We find that kinesin moves with 8-nm steps.
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