Diagnostic Direct DNA Sequencing and Systemic Treatment with Voriconazole in Scedosporium apiospermum Keratitis? A Case Report

Scedosporium apiospermum keratitis is a rare but challenging infection because of its high misidentification rate and resistance to many antifungal agents. A 35-year-old immunocompetent man with severe Scedosporium apiospermum keratitis diagnosed by both microbiology and DNA sequencing methods, which was successfully treated with systemic voriconazole was reported. Diagnosis and drug susceptibilities were discussed.