Resting-state SEEG-based brain network analysis for the detection of epileptic area

Most epilepsy research is based on interictal or ictal functional connectivity . However, prolonged electrode implantation may affect patients’ health and the accuracy of epileptic zone identification. Brief resting-state SEEG recordings reduce the observation of epileptic discharges by reducing electrode implantation and other seizure-inducing interventions. The location coordinates of SEEG in the brain were identified using CT and MRI. Based on undirected brain network connectivity, five functional connectivity measures and data feature vector centrality were calculated. Network connectivity was calculated from multiple perspectives of linear correlation, information theory, phase, and frequency, and the relative influence of nodes on network connectivity was considered. We investigated the potential value of resting-state SEEG for epileptic zone identification by comparing the differences between epileptic and non-epileptic zones, as well as the differences between patients with different surgical outcomes. By comparing the centrality of brain network connectivity between epileptic and non-epileptic zones, we found significant differences in the distribution of brain networks between the two zones. There was a significant difference in brain network between patients with good surgical outcomes and those with poor surgical outcomes (p < 0.01). By combining support vector machines with static node importance, we predicted an AUC of 0.94 ± 0.08 for the epilepsy zone. The results illustrated that nodes in epileptic zones are distinct from those in non-epileptic zones. Analysis of resting-state SEEG data and the importance of nodes in the brain network may contribute to identifying the epileptic zone and predicting the outcome. • Resting-state SEEG data from 15 patients with epilepsy were analyzed, and the AUC for predicting seizures was 0.94 ± 0.08. • Connectivity was calculated from the perspectives of linear correlation, information theory, phase, and frequency. • Significant differences in brain network distribution of resting-state SEEG data in epilepsy patients (p < 0.01). • Resting-state SEEG may be potentially valuable for identifying epileptic regions.