血小板生成素
丝氨酸
骨髓
癌症研究
下调和上调
多发性骨髓瘤
巨核细胞
医学
化学
细胞生物学
生物
免疫学
造血
磷酸化
生物化学
干细胞
基因
作者
Chunmei Kuang,Meijuan Xia,Gang An,Cuicui Liu,Cong Hu,Jingyu Zhang,Zhenhao Liu,Bin Meng,Pei Su,Jiliang Xia,Jiaojiao Guo,Yanjun Zhu,Xing Liu,Xuan Wu,Yi Shen,Xiangling Feng,Yanjuan He,Jian Li,Lugui Qiu,Jiaxi Zhou,Wen Zhou
标识
DOI:10.1038/s41467-023-37699-z
摘要
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells into the bone marrow microenvironment, as a key metabolic factor that suppresses megakaryopoiesis and thrombopoiesis. The impact of excessive serine on thrombocytopenia is mainly mediated through the suppression of megakaryocyte (MK) differentiation. Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately leading to the impairment of megakaryopoiesis. Inhibition of serine utilization or treatment with TPO enhances megakaryopoiesis and thrombopoiesis and suppresses MM progression. Together, we identify serine as a key metabolic regulator of thrombocytopenia, unveil molecular mechanisms governing MM progression, and provide potential therapeutic strategies for treating MM patients by targeting thrombocytopenia.
科研通智能强力驱动
Strongly Powered by AbleSci AI