IL-21 Shapes the B Cell Response in a Context-Dependent Manner
背景(考古学)
生物
古生物学
作者
Youngjun Kim,Francesca Manara,Simon Grassmann,Kalina T. Belcheva,Kanelly Reyes,Hyunu Kim,Stephanie Downs‐Canner,William T. Yewdell,Joseph C. Sun,Jayanta Chaudhuri
The cytokine interleukin-21 (IL-21) is a pivotal T cell-derived signal crucial for germinal center (GC) responses, but the precise mechanisms by which IL-21 influences B cell function remain elusive. Here, we investigated the B cell-intrinsic role of IL-21 signaling by employing a novel IL-21 receptor (