Integration of scRNA-seq and bulk RNA-seq reveals that macrophage ferroptosis inhibits MSC osteogenic differentiation in inflammatory microenvironments

Inhibiting macrophage ferroptosis promoted the polarization of macrophages towards the M2 phenotype, alleviated MSC PANoptosis, and promoted bone regeneration in the inflammatory microenvironment. This study provides a novel perspective on the pathological mechanisms of bone infections and identifies potential therapeutic targets.