Inulin: Unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics

生物医学 菊粉 药物输送 生物高聚物 靶向给药 纳米技术 医学 化学 生物 生物信息学 材料科学 生物化学 有机化学 聚合物
作者
Wasim Akram,Vikas Pandey,Rajeev Sharma,Ramakant Joshi,Neeraj Mishra,Navneet Garud,Tanweer Haider
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:259: 129131-129131
标识
DOI:10.1016/j.ijbiomac.2023.129131
摘要

In recent years, inulin has gained much attention as a promising multifunctional natural biopolymer with numerous applications in drug delivery, prebiotics, and therapeutics. It reveals a multifaceted biopolymer with transformative implications by elucidating the intricate interplay between inulin and the host, microbiome, and therapeutic agents. Their flexible structure, exceptional targetability, biocompatibility, inherent ability to control release behavior, tunable degradation kinetics, and protective ability make them outstanding carriers in healthcare and biomedicine. USFDA has approved Inulin as a nutritional dietary supplement for infants. The possible applications of inulin in biomedicine research inspired by nature are presented. The therapeutic potential of inulin goes beyond its role in prebiotics and drug delivery. Recently, significant research efforts have been made towards inulin's anti-inflammatory, antioxidant, and immunomodulatory properties for their potential applications in treating various chronic diseases. Moreover, its ability to reduce inflammation and modulate immune responses opens new avenues for treating conditions such as autoimmune disorders and gastrointestinal ailments. This review will attempt to illustrate the inulin's numerous and interconnected roles, shedding light on its critical contributions to the advancement of healthcare and biomedicine and its recent advancement in therapeutics, and conclude by taking valuable insights into the prospects and opportunities of inulin.
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