Laser speckle contrast imaging based on uniting spatiotemporal Fourier transform

We propose a laser speckle contrast imaging method based on uniting spatiotemporal Fourier transform. First, the raw speckle images are entirely transformed to the spatiotemporal frequency domain with a three-dimensional (3D) fast Fourier transform. Second, the dynamic and static speckle components are extracted by applying 3D low-pass and high-pass filtering in the spatiotemporal frequency domain and inverse 3D Fourier transform. Third, we calculate the time-averaged modulation depth with the average of both components to map the two-dimensional blood flow distribution. The experiments demonstrate that the proposed method could effectively improve computational efficiency and imaging quality.