萧条(经济学)
神经炎症
抗抑郁药
医学
单胺类神经递质
促炎细胞因子
炎症
精神科
内科学
焦虑
血清素
受体
经济
宏观经济学
作者
Jianbo Chang,Tao Jiang,Xiaoqian Shan,Mingxing Zhang,Yujiao Li,Xiaojun Qi,Yuhong Bian,Liang Zhao
标识
DOI:10.1016/j.pnpbp.2023.110931
摘要
Stress-mediated depression is one of the common psychiatric disorders with a high prevalence and suicide rate, there is a lack of effective treatment. Accordingly, effective treatments with few adverse effects are urgently needed. Pro-inflammatory cytokines (PICs) may play a key role in stress-mediated depression. Thereupon, both preclinical and clinical studies have found higher levels of IL-1β, TNF-α and IL-6 in peripheral blood and brain tissue of patients with depression. Recent studies have found PICs cause depression by affecting neuroinflammation, monoamine neurotransmitters, hypothalamic pituitary adrenal axis and neuroplasticity. Moreover, they play an important role in the symptom, development and progression of depression, maybe a potential diagnostic and therapeutic marker of depression. In addition, well-established antidepressant therapies have some relief on high levels of PICs. Importantly, anti-inflammatory drugs relieve depressive symptoms by reducing levels of PICs. Collectively, reducing PICs may represent a promising therapeutic strategy for depression.
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