医学
内科学
四分位数
萧条(经济学)
前瞻性队列研究
怀孕
爱丁堡产后忧郁量表
产后抑郁症
队列
逻辑回归
混淆
队列研究
中性粒细胞与淋巴细胞比率
产科
淋巴细胞
抑郁症状
置信区间
内分泌学
糖尿病
生物
经济
宏观经济学
遗传学
作者
Ya Zhang,Maochun Hong,Han Xiao,Yuanyuan Zhang,Wenqi Gao,M.D. Haiqin Qi,Jianduan Zhang
标识
DOI:10.1016/j.jpsychores.2022.111101
摘要
The prevalence of depression has increased dramatically in the past few decades, and pregnant women are at high risk for depression. It is widely thought that inflammation plays a critical role in the pathogenesis of depression. Therefore, we aimed to evaluate the association between the neutrophil-lymphocyte ratio (NLR), a marker of chronic immune inflammation, and perinatal depressive symptoms.A cohort study involving 535 pregnant women was conducted based on a prospective birth cohort in Wuhan, China. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess antepartum depression (APD) and postpartum depression (PPD) during the second trimester of pregnancy and one month after delivery. The NLR during the second trimester was determined based on a routine blood test. The association between NLR and depressive symptoms was evaluated using logistic regression analysis and restricted cubic spline (RCS) regression.We found that the prevalence of APD and PPD was 8.4% and 15.1%, respectively. NLR levels were positively associated with APD (OR = 1.52, 95% CI: 1.20--1.91). After adjusting for potential confounders, the OR (95% CI) of APD for the highest NLR quartile was 4.56 (1.58, 13.13) compared with the lowest quartile. No significant association was found between NLR and PPD. RCS regression model analysis indicated a linear correlation between NLR and APD (P for non-linearity = 0.58).Overall, elevated mid-trimester NLR is independently associated with APD but not PPD.
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