明胶
自愈水凝胶
嵌合抗原受体
黑色素瘤
癌症研究
免疫疗法
肿瘤微环境
体外
材料科学
医学
药理学
肿瘤细胞
免疫学
免疫系统
化学
高分子化学
生物化学
作者
Weilin Zhou,Sibei Lei,Mei Liu,Dan Li,Yong Huang,Xiaoyi Hu,Jing Yang,Jing Li,Maorong Fu,Mengxi Zhang,Fenglin Wang,Jiaqian Li,Ke Men,Wei Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2022-12-01
卷期号:291: 121872-121872
被引量:9
标识
DOI:10.1016/j.biomaterials.2022.121872
摘要
The chimeric antigen receptor-T cells (CAR-T) therapy, as a novel personalized immunotherapy, has shown prominent clinical efficacy in the treatment of B-cell malignancies. However, the progress in solid tumors was hindered by multiple elements in the tumor immunosuppressive microenvironment. In this study, an injectable and photocurable Gelatin Methacryloyl (GelMA) hydrogel was applied to be a depot of CAR-T cells, thus forming an injectable CAR-T Gelatin Methacryloyl hydrogels Delivery (i-GMD) system. According to our results, CAR-T cells in this system could be normally amplified, sustained released, and play an anti-tumor role in vitro. When compared with local or intravenously injection of CAR-T solution, injection of i-GMD matrix around tumor demonstrated enhanced anti-tumor effect and markedly extended survival of mice. Our research outcomes indicated that this therapeutic strategy might hopefully provide a treatment for patients with unresectable tumors.
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