聚酮
化学
链霉菌
立体化学
赫拉
肽
大肠杆菌
圆二色性
衍生化
组合化学
生物合成
生物化学
细菌
基因
体外
质谱法
生物
遗传学
色谱法
作者
Zhiguo Liu,Yoko Yashiroda,Peng Sun,Ma Hai,Yanan Wang,Li Li,Fu Yan,Yi Sun
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-05
卷期号:25 (4): 571-575
被引量:3
标识
DOI:10.1021/acs.orglett.2c03290
摘要
Two novel glycosylated polyketide–peptide hybrid macrolides, argenteolides A (1) and B (2), were isolated from an actinomycete Streptomyces argenteolus. Argenteolide A (1) contains a unique 5/5/5 tricyclic system in a 20-membered macrocycle. Their structures were elucidated by extensive spectroscopic analysis, and their stereochemical configurations were established through the application of chemical derivatization, J-based configuration analysis, DP4+ calculation, and electronic circular dichroism calculation. The analysis of the genome sequence revealed a plausible biosynthesis mechanism, and isotope-labeled feeding studies suggested their biogenetic origins. Argenteolides A and B exhibited moderate cytotoxicities against A549, p388, and Hela human carcinoma cell lines as well as antibacterial activities against Staphylococcus aureus and Escherichia coli ATCC25922.
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