胶质瘤
异柠檬酸脱氢酶
有效扩散系数
医学
核医学
磁共振成像
接收机工作特性
生物标志物
磁共振弥散成像
成像生物标志物
病理
放射科
生物
癌症研究
内科学
核磁共振
物理
遗传学
酶
作者
Xiaoxiao Ma,Kun Cheng,Gang Cheng,Chenxi Li,Jinhao Lyu,Yina Lan,Caohui Duan,Xiaowei Bian,Jianning Zhang,Xin Lou
摘要
Glioma genotypes are of importance for clinical decision-making. This data can only be acquired through histopathological analysis based on resection or biopsy. Consequently, there is a need for alternative biomarkers that noninvasively provide reliable information for preoperatively identifying molecular characteristics.To investigate apparent diffusion coefficient (ADC) as imaging biomarker for preoperatively identifying glioma genotypes based on the 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors.Retrospective.One hundred and fifty-nine patients (47.6 ± 14.4 years) diagnosed with WHO grade 2-4 glioma including 93 males and 66 females.A 3 T/spin echo echo planner imaging.The ADC measurements were assessed by two neuroradiologists (both with 6 years of experience). Three different lowest portions inside the tumors without overlap were manually drawn on the ADC maps as regions of interest (ROIs). The mean ADC value of the three ROIs was defined as the minimum ADC value (ADCmin ). An ROI was placed in the contralateral normal appearing white matter (NAWM) to obtain the ADC value (ADCNAWM ). The ADCmin to ADCNAWM ratio (ADCratio ) was calculated. Genetics results were retrospectively recorded from pathologic and genetic test reports.Two-sample independent t-tests, receiver operating characteristic curve analysis, and intraclass correlation coefficient analysis were used. Statistical significance was set at P < 0.05.Isocitrate dehydrogenase (IDH)-mutated glioma showed higher ADCmin and ADCratio than IDH wild-type glioma. Among IDH-mutated glioma, higher ADCmin and ADCratio were found in 1p19q intact glioma than in 1p19q codeletion glioma. ADC parameters enabled differentiation of IDH mutation status with area under the curve (AUC) of 0.84 and 0.86.ADC has potential discriminative value for IDH mutation and 1p19q codeletion status.3.Stage 2.
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