化学
烷基
沸石
芳基
酮
溶剂
有机化学
硅胶
吸附
水解
氨
缩合反应
催化作用
药物化学
作者
Shintaro Shibata,Yoichi Masui,Naoki Narukawa,Takuya Shiroshita,Hiroyuki Miya,Rie Sato,Shoichi Tokutake,Yoshiki Tanaka,Makoto Onaka
标识
DOI:10.1246/bcsj.20230055
摘要
The most atom-efficient synthetic method for N-unprotected ketimines (N-H ketimines) from ketones is the dehydration condensation reaction with ammonia (NH3). However, until now, few synthetic methods for N-H ketimines with high versatility have been known. In this study, we examined various solid acids and found that N-H diaryl ketimines with various functional groups on the aryl groups could be synthesized in high yields from diaryl ketones and NH3 under solvent-free conditions using silica-alumina (SiO2-Al2O3) or proton-exchanged Y-type zeolite (H-Y). Solid-state 13C and 15N NMR measurements indicated that the N-H ketimine formed in the pores of acidic zeolite was coordinated to NH4+ species on the pore surface. By quantum chemical calculations we also discussed the reason why the dehydration-condensation reaction between ketone and NH3, which is an endothermic reaction in a vacuum, was biased toward the product side in the actual experiment. In addition, this synthetic method can be applied to synthesize N-H alkyl ketimines with α-acidic hydrogens, which are less stable and more sensitive to hydrolysis and oligomerization than diaryl ketimines. We discovered that N-H diaryl ketimines with various functional groups on the aryl groups were able to synthesize in high yields from the diaryl ketones and NH3 under solvent-free conditions using silica-alumina (SiO2-Al2O3) or proton-exchanged Y-type zeolite (H-Y). In addition, this synthetic method can be applied to synthesize more labile N-H alkyl ketimines with α-acidic hydrogens.
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