Perdeuteration of (Hetero)arenes in Flow Enabled by Defective Porous Carbon

Deuterium incorporation in organic compounds has been widely applied in medicinal chemistry and materials science. Specifically, fully deuterated aromatic compounds are frequently applied in organic light‐emitting diodes. For this application, there is a growing interest in the development of methods for perdeuteration. Herein, a general and scalable method for constructing perdeuterated (hetero)arenes using carbon materials via hydrogen isotope exchange reaction is described. Defective porous carbon material is generated by pyrolyzing cellulose, which permits perdeuteration of arenes and heteroarenes using inexpensive and easy‐handling D 2 O as the deuterium source. Materials characterization and mechanistic studies reveal that vacancy‐defect O ‐doped porous‐carbon is generated after pyrolyze cellulose and D species in pores could be formed under continuous flow. This methodology represents a cost‐effective methodology for scalable deuteration and enables efficient labeling in a straightforward manner.