Complete Cytoreduction of Colorectal Liver Metastases: Evolving Systemic Therapy and Liver Transplantation

ABSTRACT Approximately 50%–60% of patients with colorectal cancer develop metastases, of which most have unresectable metastatic liver disease. Several recent studies highlight the progress of systemic therapy in converting patients with high burden of colorectal liver metastases (CRLM) from unresectable to resectable disease, resulting in median overall survival improvements. The improvement of systemic therapy and the evolving spectrum of surgical techniques is allowing multidisciplinary treatment teams an increasing ability to achieve complete cytoreduction of CRLM and offering an increasing number of patients a chance for long‐term survival.