Sex-Specific Association between Anatomic Variants of the Circle of Willis and Intracranial Aneurysms in Individuals with a Familial Predisposition

Women with intracranial aneurysms identified at screening less frequently had a normal anterior part of the CoW compared with those without aneurysms. Additionally, individuals with aneurysms more often had anterior communicating artery hypoplasia or absence, which association was not sex-specific. These anatomic variations may enhance the effectiveness of screening for intracranial aneurysms.