A Polyplatin with Hands‐Holding Near‐Infrared‐II Fluophores and Prodrugs at a Precise Ratio for Tracking Drug Fate with Realtime Readout and Treatment Feedback

The in vivo fate of chemotherapeutic drugs plays a vital role in helping the understanding of the therapeutic outcome, side effects, and the mechanism of action. However, the lack of imaging abilities of most drugs, tedious labelling processes, and premature leakage of imaging agents currently result in loss of fidelity between the drugs and any imaging signals. Herein, an unique amphiphilic polymer was created by copolymerization of a NIR-II fluorophore drug tracer (T) and an anticancer Pt(IV) prodrug (D) of cisplatin in a hand-holding manner into one polymer chain for the first time. The obtained Polyplatin