Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond

Flavonoids are bioactive compounds derived from plants that play a crucial role in human health. Baicalein is a prominent phytoconstituent with multifaceted therapeutic potential against various diseases. This review explores recent advancements in understanding baicalein's hepatoprotective action against different toxicity models (acetaminophen, cisplatin, doxorubicin, CCL4, monocrotaline, & d-galactosamine). Furthermore, we report the key pharmacological activities of baicalein against neurotoxicity (6-OHDA, rotenone, d-galactose, stroke, alzheimer, & sclerosis), inflammation (arthritis, pulmonary fibrosis, & LPS-induced sepsis), cancer (breast, prostate, gall bladder, gastric, & pancreatic), & diabetes. Overall, baicalein has potential to influence diverse biological networks, making it a promising candidate for both dietary supplementation and therapeutic development.