化学
废止
噻唑烷
组合化学
立体选择性
立体化学
有机化学
催化作用
作者
Yuhao Ding,Haiheng Guo,Jingwen Fan,Zhiyong Li,Guolin Cheng
标识
DOI:10.1002/adsc.202300896
摘要
Abstract 2‐Iminothiazolidin‐4‐one, 5‐ethylidenethiazolidin‐4‐one, and thiazolidine‐4‐thione are all medicinally relevant structures. In this work, a NaSO 2 CF 3 ‐promoted [2+2+1] cascade annulation reaction of CF 3 ‐imidoyl sulfoxonium ylides and isothiocyanates was reported to synthesize a variety of decorated thiazolidine‐4‐thiones in 35–91% yields with exclusive stereoselectivity. The gram‐scale reaction and further chemoselective S ‐alkylations demonstrated the synthetic utilities of this transformation.
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