视神经脊髓炎
医学
视神经炎
多发性硬化
生物标志物
光谱紊乱
脊髓炎
免疫学
重症监护医学
精神科
生物化学
化学
脊髓
作者
Ruoyi Guo,W Wang,Jingying Huang,Zhang Jia,Yuchun Sun,Bin Li
标识
DOI:10.1177/13524585231212832
摘要
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a group of inflammatory diseases affecting the central nervous system, characterized by optic neuritis and myelitis. The complex nature of NMOSD and varied patient response necessitates personalized treatment and efficient patient stratification strategies. Objective: To provide a comprehensive review of recent advances in clinical and biomarker research related to aquaporin-4 (AQP4)-immunoglobulin G (IgG)-seropositive NMOSD prognosis and identify key areas for future research. Methods: A comprehensive review and synthesis of recent literature were conducted, focusing on demographic factors and laboratory investigations. Results: Demographic factors, such as age, ethnicity, and sex, influence NMOSD prognosis. Key biomarkers for NMOSD prognosis include homocysteine, antinuclear antibodies, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, thyroid hormone levels, neurofilament light chain levels, and serum glial fibrillary acidic protein might also predict NMOSD attack prognosis. Conclusion: Further investigation is required to understand sex-related disparities and biomarker inconsistencies. Identification and understanding of these factors can aid in the development of personalized therapeutic strategies, thereby improving outcomes for NMOSD patients. Future studies should focus on unifying research design for consistent results.
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