化学
磷化氢
钋
环加成
烯烃
磷
维蒂希反应
药物化学
光催化
光化学
有机化学
催化作用
作者
Yusuke Masuda,Daichi Ikeshita,Kosuke Higashida,Masaki Yoshida,Naoki Ishida,Masahiro Murakami,Masaya Sawamura
摘要
Tri(t-butyl)phosphine and terminal alkynes undergo 1,2-phosphorus-migrative [3 + 2] cycloaddition in the presence of a proton source under photocatalytic conditions. The reaction exhibits broad functional group tolerance and affords substituted cyclic phosphonium salts, which are amenable to further derivatization by Wittig olefination. Theoretical studies suggest that the phosphorus 1,2-migration of a β-phosphonioalkyl radical proceeds through a phosphine radical cation-alkene complex as a pseudointermediate, and the two fragments in the intermediate are bound to each other through multiple noncovalent interactions.
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