Synthesis and Photophysical Characterization of a Photoaffinity Molecular Switch

In recent years, the development of some photoswitches based on azobenzene group provides a good tool for high spatio-temporal and precise regulation of ion channels and protein receports, but these small molecular photoswitches are very easily diffused in organisms. To overcome this limit, we have designed a photoswitches SY1 containing photocrosslinked group diazirine. The photoswitch was synthesized by the condensation reaction between azobenzene derivative and diazirine. The structure of the compound was characterized by 1H NMR and HR-MS, and the photophysical properties of the photoswtich SY1 were studied by UV-vis spectroscopy in different solvent systems. The results show that SY1 has excellent photodependent isomerization.