化学
亲脂性
抗真菌
哌嗪
三唑
酵母
立体化学
连接器
化学合成
组合化学
1,2,3-三唑
有机化学
体外
生物化学
微生物学
操作系统
生物
计算机科学
作者
Svetlana V. Blokhina,Тatyana V. Volkova,Marina V. Ol’khovich,Irina A. Doroshenko,I. B. Levshin,German L. Perlovich
标识
DOI:10.1016/j.bmcl.2021.127944
摘要
Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.
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