荧光
纳米技术
纳米团簇
生物传感器
材料科学
碳纳米管
共轭体系
分析物
量子点
近红外光谱
化学
聚合物
量子力学
物理
物理化学
复合材料
作者
Liang Gong,Xiuzhi Shan,Xu-Hua Zhao,Li Tang,Xiaobing Zhang
出处
期刊:ChemMedChem
[Wiley]
日期:2021-04-30
卷期号:16 (16): 2426-2440
被引量:20
标识
DOI:10.1002/cmdc.202100142
摘要
With the advantage of inherent responsiveness that can change the spectroscopic signals from "off" to "on" state in responding to targets (e. g. biological analytes/microenvironmental factors), activatable fluorescent probes have attracted extensive attention and made significant progress in the field of bioimaging and biosensing. Due to the high depth of tissue penetration, minimal tissue damage and negligible background signal at longer wavelengths, the development of second near-infrared window (NIR-II) fluorescent materials provides a new opportunity to develop activable fluorescent probes. Here, we summarized properties, advantages and disadvantages of mainly NIR-II fluorophores (such as rare earth-doped nanoparticles, quantum dots, single-walled carbon nanotubes, small molecule dyes, conjugated polymers and gold nanoclusters), then overviewed current role and development of activatable NIR-II fluorescent probes (AFPs) for biomedical applications including biosensing, bioimaging and therapeutic. The potential challenges and perspectives of AFPs in deep-tissue imaging and clinical application are also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI