钙粘蛋白
肌动蛋白
细胞生物学
张力(地质)
生物物理学
粘附
化学
光学镊子
连环素
细胞粘附
细胞
生物
物理
信号转导
生物化学
经典力学
光学
Wnt信号通路
有机化学
力矩(物理)
作者
Craig Buckley,Jiongyi Tan,Karen Anderson,Dorit Hanein,Niels Volkmann,William I. Weis,W. James Nelson,Alexander R. Dunn
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2014-10-31
卷期号:346 (6209)
被引量:534
标识
DOI:10.1126/science.1254211
摘要
Pulling me apart only makes me stronger Tension transmitted between neighboring cells can exert profound effects on cell proliferation, differentiation, and tissue organization. Exactly how intercellular mechanical tension is sensed at the molecular level is unknown. One attractive hypothesis is that a linkage between the cell-cell adhesion molecule E-cadherin, its binding partners α- and β-catenin, and actin filaments may act as a tension sensor. However, how this linkage is established at the molecular level is not known. Buckley et al. used optical tweezers to determine how mechanical load influences interactions of the cadherin/catenin complex with single actin filaments. The data support a model in which force shifts the interaction from a force-independent, weakly bound state to a highly force-sensitive, strongly bound state. The findings may explain how cells maintain tissue integrity while still being able to move and change shape. Science , this issue p. 10.1126/science.1254211
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