纤维化
胚胎干细胞
生物
基质
伤口愈合
谱系(遗传)
真皮
细胞外基质
结缔组织
病理
细胞生物学
癌症研究
解剖
免疫组织化学
医学
免疫学
基因
遗传学
作者
Yuval Rinkevich,Graham G. Walmsley,Michael S. Hu,Zeshaan N. Maan,Aaron M. Newman,Micha Drukker,Michael Januszyk,Geoffrey W. Krampitz,Geoffrey C. Gurtner,H. Peter Lorenz,Irving L. Weissman,Michael T. Longaker
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-04-17
卷期号:348 (6232)
被引量:519
标识
DOI:10.1126/science.aaa2151
摘要
Fibroblasts in fibrosis Excess fibrous connective tissue, similar to scarring, forms during the repair of injuries. Fibroblasts are known to be involved, but their role is poorly characterized. Rinkevich et al. identify two lineages of dermal fibroblasts in the dorsal skin of mice (see the Perspective by Sennett and Rendl). A fibrogenic lineage, defined by embryonic expression of Engrailed-1 , plays a central role in dermal development, wound healing, radiation-induced fibrosis, and cancer stroma formation. Targeted inhibition of this lineage results in reduced melanoma growth and scar formation, with no effect on the structural integrity of the healed skin, thus indicating therapeutic approaches for treating fibrotic disease. Science , this issue 10.1126/science.aaa2151 ; see also p. 284
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