剪应力
剪切(地质)
内皮
剪切速率
体内
材料科学
复合材料
流变学
医学
内科学
生物
生物技术
作者
Natacha DePaola,Michael A. Gimbrone,Peter F. Davies,C. Forbes Dewey
出处
期刊:Arteriosclerosis and thrombosis
[Ovid Technologies (Wolters Kluwer)]
日期:1992-11-01
卷期号:12 (11): 1254-1257
被引量:400
标识
DOI:10.1161/01.atv.12.11.1254
摘要
In vitro investigations of the responses of vascular endothelium to fluid shear stress have typically been conducted under conditions where the time-mean shear stress is uniform. In contrast, the in vitro experiments reported here have re-created the large gradients in surface fluid shear stress found near arterial branches in vivo; specifically, we have produced a disturbed-flow region that includes both flow separation and reattachment. Near reattachment regions, shear stress is small but its gradient is large. Cells migrate away from this region, predominantly in the downstream direction. Those that remain divide at a rate that is high compared with that of cells subjected to uniform shear. We speculate that large shear stress gradients can induce morphological and functional changes in the endothelium in regions of disturbed flow in vivo and thus may contribute to the formation of atherosclerotic lesions.
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