化学
对映选择合成
双环分子
蒽酮
催化作用
胍
加合物
有机化学
Diels-Alder反应
有机催化
作者
Juan Shen,Thanh Truc Nguyen,Yong‐Peng Goh,Weiping Ye,Fu Xiao,Junye Xu,Choon‐Hong Tan
摘要
Chiral bicyclic guanidine 1 was found to be an excellent catalyst for reactions between anthrones and various dienophiles. The catalyst can tolerate a range of substituents and substitution patterns, making several anthrone derivatives suitable for this reaction. Both Diels−Alder and Michael adducts were obtained in excellent yields, high regioselectivities, and high enantioselectivities. This is the first case of a highly enantioselective base-catalyzed anthrone Diels−Alder reaction.
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