光热治疗
催化作用
癌症治疗
活性氧
肿瘤微环境
癌细胞
分解
化学
转移
纳米技术
肿瘤细胞
材料科学
癌症研究
组合化学
医学
生物化学
癌症
内科学
有机化学
作者
Lei Jiao,Na Tao,Yikun Kang,Weiyu Song,Yifeng Chen,Yu Zhang,Weiqing Xu,Yu Wu,Wenling Gu,Lirong Zheng,Limiao Chen,You‐Nian Liu,Chengzhou Zhu,You‐Nian Liu
出处
期刊:Nano Today
[Elsevier]
日期:2023-06-01
卷期号:50: 101859-101859
被引量:8
标识
DOI:10.1016/j.nantod.2023.101859
摘要
Achieving efficient activation of H2O2 in the tumor microenvironment (TME) and further improving the therapeutic efficiency is a great challenge in chemodynamic therapy against cancer. Herein, inspired by natural enzymes, atomically dispersed catalysts with Fe-Cu hetero-binuclear active sites on hollow nitrogen-doped carbon nanospheres (FeCuNC) are synthesized as catalytic nanomedicines for cancer therapy. We found that Fe-Cu hetero-binuclear sites in FeCuNC can catalytically dissociate the O–O bonds in H2O2 molecules more easily than those of single-Fe sites. Besides, the intrinsic photothermal effect of FeCuNC not only further accelerates H2O2 decomposition to produce abundant reactive oxygen species but also achieves synergistically chemodynamic therapy and photothermal therapy to induce cancer cell apoptosis and restrain tumor growth. Moreover, FeCuNC can accurately identify sentinel lymph node metastasis and effectively suppress tumor metastasis and recurrence. This work will provide an advanced strategy for the design of advanced catalysts for H2O2 activation in TME, which holds great promise for practical clinical applications.
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