A butyrolactone derivative from marine-derived fungal strain Aspergillus terreus BTBU20211037

The secondary metabolites of marine-derived fungal strain, Aspergillus terreus BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (1), and twelve known compounds, butyrolactone I (2), butyrolactone VI (3), aspernolide B (4), aspernolide A (5), 7'-hydroxybutyrolactone III (6), methyl asterrate (7), methyl dichloroasterrate (8), sulochrin (9), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (10), serantrypinone (11), alantrypinone (12), and territrem A (13). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds 1, 10, and 13 showed inhibitory effects against Staphylococcus aureus ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.