乳腺癌
氧化应激
活性氧
三阴性乳腺癌
癌症研究
恶性肿瘤
缺氧(环境)
4-羟基壬醛
癌症
转录因子
间质细胞
内科学
化学
脂质过氧化
医学
病理
生物化学
氧气
基因
有机化学
作者
Tomislav Orešić,Sanda Bubanović,Snježana Ramić,Božena Šarčević,Ana Čipak Gašparović
标识
DOI:10.1016/j.prp.2023.154662
摘要
Breast cancer is one of the leading causes of cancer-related mortality in women. During tumor growth, periods of hypoxia are followed by reoxygenation due to neovascularisation leading to disturbed redox homeostasis. ROS (Reactive Oxygen Species) produced under hypoxia activate HIF1α. ROS can also activate the major antioxidant transcription factor NRF2, but also cause damage to biomolecules. Lipids are susceptible to peroxidation, as evidenced by the formation of reactive aldehydes, among which, HNE (4-hydroxynonenal) is the most studied one. Knowing that HIF1α (Hypoxia Inducing Factor 1α) is associated with breast cancer malignancy, we aimed to investigate its correlation with HNE and NRF2 (Nuclear factor erythroid 2-related factor 2). Our results show that HIF1α is activated in breast cancer, indicating an increase in ROS but not followed by HNE production. On the other hand, NRF2 was increased in all types of breast cancer suggesting that oxidative stress is present in these pathologies, but also supporting HIF1α. Interestingly, NRF2 was activated in HER2 positive and TNBC, indicating the role of stromal NRF2 in breast cancer malignancy.
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