Re: Effect of glioma-derived immunoglobulin on biological function of glioma cells: The emerging roles of immunoglobulins in the tumor immune microenvironment

In a recently published article in the European Journal of Cancer, Jiaoyun Lv et al. reported that immunoglobins were expressed in clinical tissues and cell lines derived from glioma and associated with a poor prognosis. Moreover, this study illustrated how immunoglobins from glioma promote malignant proliferation and migration through the HGF/SF-Met or FAK/Src pathway in vitro and in vivo [ [1] Lv J. Chen S. Chen X. Xie J. He Z. Fan T. et al. Effect of glioma-derived immunoglobulin on biological function of glioma cells. Eur J Cancer. 2022; 175: 86-98 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar ]. The immunoglobins are widely distributed in the blood, tissue fluid, and exocrine fluid, primarily maintaining humoral immunity by binding to the exogenous antigen. In keeping with that notion, classical immunology theory considered B cells the primary source of immunoglobin in circulation. Since the heavy chains of immunoglobins were detected in cancer cell lines, increasing evidence has demonstrated that solid cancer and benign hyperplasia tissues, in addition to lymphoma, could also express and secrete immunoglobins [ 2 Kimoto Y. Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines. Genes Chromosomes Cancer. 1998; 22: 83-86 Crossref PubMed Scopus (67) Google Scholar , 3 Li M. Feng D.Y. Ren W. Zheng L. Zheng H. Tang M. et al. Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells. Int J Biochem Cell Biol. 2004; 36: 2250-2257 Crossref PubMed Scopus (51) Google Scholar , 4 Niu N. Zhang J. Huang T. Sun Y. Chen Z. Yi W. et al. IgG expression in human colorectal cancer and its relationship to cancer cell behaviors. PLoS One. 2012; 7e47362 Crossref Scopus (43) Google Scholar ]. However, the molecular and biological role of tumor-derived immunoglobins remains largely unknown. Effect of glioma-derived immunoglobulin on biological function of glioma cellsEuropean Journal of CancerVol. 175PreviewGlioma is the most common and most invasive primary central nervous system tumour, and it is urgent to develop new specific therapeutic targets. Studies have confirmed that epithelial-derived tumour cells promote tumour cell proliferation and metastasis by secreting a large number of immunoglobulins (Igs), but the role of tumour-derived Igs in glioma has never been reported. Full-Text PDF