粒体自噬
自噬
纳米颗粒
癌细胞
帕金
纳米技术
生物相容性
活性氧
细胞凋亡
癌症
化学
PI3K/AKT/mTOR通路
癌症治疗
细胞生物学
材料科学
癌症研究
生物
医学
生物化学
有机化学
帕金森病
疾病
病理
遗传学
作者
Deepa Mundekkad,William C. Cho
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-10-24
卷期号:14 (11): 2275-2275
被引量:5
标识
DOI:10.3390/pharmaceutics14112275
摘要
Research on nanoparticles, especially metal nanoparticles, in cancer therapy is gaining momentum. The versatility and biocompatibility of metal nanoparticles make them ideal for various applications in cancer therapy. They can bring about apoptotic cell death in cancer cells. In addition to apoptosis, nanoparticles mediate a special type of autophagy facilitated through mitochondria called mitophagy. Interestingly, nanoparticles with antioxidant properties are capable of inducing mitophagy by altering the levels of reactive oxygen species and by influencing signaling pathways like PINK/Parkin pathway and P13K/Akt/mTOR pathway. The current review presents various roles of metal nanoparticles in inducing mitophagy in cancer cells. We envision this review sheds some light on the blind spots in the research related to mitophagy induced by nanoparticles for cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI