Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

ABSTRACT This systematic review and meta‐analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis ( AD ) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well‐tolerated treatment for AD .