生物医学
疾病
癌症
细菌
医学
药物输送
生物
纳米技术
计算生物学
生物信息学
病理
内科学
遗传学
材料科学
作者
Yong Liu,Wenqin Yu,Qian Wang,Zhenping Cao,Juanjuan Li
标识
DOI:10.1016/j.drudis.2023.103667
摘要
Therapeutics based on living organisms provide a roadmap for next-generation biomedicine. Bacteria have an essential role in the development, regulation, and treatment of gastrointestinal disease and cancer through similar mechanisms. However, primitive bacteria lack the stability to overcome complex drug delivery barriers, and their multifunctionality in reinforcing both conventional and emerging therapeutics is limited. Artificially engineered bacteria (ArtBac) with modified surfaces and genetic functions show promise for tackling these problems. Herein, we discuss recent applications of ArtBac as living biomedicine for the treatment of gastrointestinal diseases and tumors. Future perspectives are given to guide the rational design of ArtBac toward safe multifunctional medicine.
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