In this work, a high-performance wearable sensor of excellent flexibility was fabricated by dip-coating Ti 3 C 2 T x MXene material (M) on a polyester fiber (PET) substrate and depositing silver nanoparticles (Ag) by magnetron sputtering. The Ag/M/PET fiber sensor not only responds well to the stimuli of temperature, pressure/strain signals, but also exhibits high temperature sensitivity (0~10 °C: -3.4938 % °C -1 , 10~30 °C: -1.0436 % °C -1 ), relatively fast response and recovery time to pressure (130 ms), low-pressure detection limit (6.5 mg, 1 cm 2 ), and good cycling stability (1000 cycles). The proposed fiber sensor has the advantages of high sensitivity, simple structure, convenient fabrication, and excellent multimodal sensing capability, which makes it a valuable candidate for human motion detection and personal healthcare.