结直肠癌
生物
免疫系统
免疫疗法
染色质
调节器
癌症免疫疗法
癌症
癌症研究
生物信息学
计算生物学
免疫学
基因
遗传学
作者
Xiaopeng Li,Xiongwei Huo,Chenye Zhao,Zilu Chen,Zhengshui Xu,Junhui Yu,Xuejun Sun
出处
期刊:Epigenomics
[Future Medicine]
日期:2022-11-01
卷期号:14 (21): 1325-1341
标识
DOI:10.2217/epi-2022-0266
摘要
Aim: To elucidate the potential function and prognostic value of chromatin regulators (CRs) in colon cancer. Materials & methods: A comprehensive analysis of CR RNA expression data from public databases was conducted. Results: The authors successfully established and validated a 17 CR-based signature using public databases. Ten CRs of the signature were eventually verified at the protein level using the Human Protein Atlas database. Functional enrichment showed that CRs were significantly enriched in cancer-related pathways. This signature was remarkably relevant to immune cell infiltration, immune checkpoints, tumor immune dysfunction and exclusion (TIDE) score and drug sensitivity. Conclusion: The authors identified a novel, reliable prognostic signature for colon cancer. The study provided new insights into the function of CRs and has important clinical implications for immunotherapy for colon cancer.
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