化学
肟
氧化磷酸化
铜
组合化学
有机化学
生物化学
作者
Nitin L. Jadhao,Harish B Musale,Jayant M. Gajbhiye,Vivek Tukaramji Humne
摘要
A new protocol for the direct synthesis of 2-aminothiazole has been developed from oxime acetate and readily available sodium thiocyanate using a copper catalyst. The present transformation has good functional group tolerance. Various thiazoles were smoothly synthesized in good to excellent yields. The applicability of the present method has been extended to the formal synthesis of the non-steroidal and anti-inflammatory drug, fentiazac via the Sandmeyer reaction and Suzuki coupling.
科研通智能强力驱动
Strongly Powered by AbleSci AI