Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3–IL22–IL22R pathway

Limonin supplementation can activate the microbiota-associated ILC3–IL22–IL22R pathway to promote pSTAT3 in intestinal epithelial cells, thereby enhancing the impaired intestinal barrier, down-regulating the expression of key lipid transporters, and ultimately improving HFD-induced dyslipidemia.